Y06036
Y06036 is a potent and selective BET inhibitor, which binds to the BRD4 (1) bromodomain with Kd value of 82 nM[1]. Antitumor activity[1].
Product Specifications
CAS Number
1832671-96-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Y06036.html
Purity
98.57
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
BrC1=CC(S(=O)(NC2=C(OC)C=C(ON=C3C)C3=C2)=O)=C(OC)C=C1
Molecular Formula
C16H15BrN2O5S
Molecular Weight
427.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang M, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) . J Med Chem. 2018 Apr 12;61 (7) :3037-3058.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Frequently Asked Questions
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