Y06036

Y06036 is a potent and selective BET inhibitor, which binds to the BRD4 (1) bromodomain with Kd value of 82 nM[1]. Antitumor activity[1].

Product Specifications

CAS Number

[1832671-96-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Y06036.html

Purity

98.57

Solubility

DMSO : 130 mg/mL (ultrasonic)

Smiles

BrC1=CC(S(=O)(NC2=C(OC)C=C(ON=C3C)C3=C2)=O)=C(OC)C=C1

Molecular Formula

C16H15BrN2O5S

Molecular Weight

427.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang M, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) . J Med Chem. 2018 Apr 12;61 (7) :3037-3058.