MC70
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].
Product Specifications
CAS Number
1031367-64-2
Product Name Alternative
OX2R antagonist
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc70.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=CC=C(CN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)C=C1
Molecular Formula
C24H25NO3
Molecular Weight
375.46
References & Citations
[1]Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'- (6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl) biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59 (14) :6729-38. |[2]Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670 (1) :74-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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