MC70

MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].

Product Specifications

CAS Number

[1031367-64-2]

Product Name Alternative

OX2R antagonist

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc70.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=CC=C(CN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)C=C1

Molecular Formula

C24H25NO3

Molecular Weight

375.46

References & Citations

[1]Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'- (6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl) biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59 (14) :6729-38. |[2]Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670 (1) :74-84.