CX614

CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2].

Product Specifications

CAS Number

[191744-13-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cx614.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC3=C(C=C2OC4N1CCC4)OCCO3

Molecular Formula

C13H13NO4

Molecular Weight

247.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105.|[2]Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970 (1-2) :221-5.