Dynole 34-2
Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) [1][2].
Product Specifications
CAS Number
1128165-88-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Dynamin
Type
Reference compound
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dynole-34-2.html
Concentration
10mM
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C(NCCCCCCCC)=O)=C\C1=CN(CCCN(C)C)C2=C1C=CC=C2
Molecular Formula
C25H36N4O
Molecular Weight
408.58
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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