Dynole 34-2

Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) [1][2].

Product Specifications

CAS Number

[1128165-88-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Dynamin

Type

Reference compound

Related Pathways

Apoptosis; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dynole-34-2.html

Concentration

10mM

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#C/C(C(NCCCCCCCC)=O)=C\C1=CN(CCCN(C)C)C2=C1C=CC=C2

Molecular Formula

C25H36N4O

Molecular Weight

408.58

Precautions

H302, H315, H319

References & Citations

[1]Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10 (9) :1553-62. |[2]Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52 (12) :3762-73.