Apilimod (hydrochloride)
Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
Product Specifications
CAS Number
870087-37-9
Product Name Alternative
STA 5326 (hydrochloride) ; LAM-002A (free base) (hydrochloride) ; AIT-101 (hydrochloride)
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apilimod-hydrochloride.html
Smiles
CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.Cl.Cl
Molecular Formula
C23H28Cl2N6O2
Molecular Weight
491.41
References & Citations
[1]The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD44v4 (Marker of Tumor Metastasis), Biotin conjugate, 0.1mg/mL
