Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GNE-617

GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.

Product Specifications

CAS Number

1362154-70-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-617.html

Purity

99.58

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(S(C2=CC(F)=CC(F)=C2)(=O)=O)C=C1)C3=CN4C(C=C3)=NC=C4

Molecular Formula

C21H15F2N3O3S

Molecular Weight

427.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19 (24) :6912-23.|[2]Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144 (1) :163-72.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

o-Nitrophenyl Beta-D-Galactopyranoside-6-phosphate, Cyclohexylammonium Salt,
TRC-N503625-50MG 50 mg

o-Nitrophenyl Beta-D-Galactopyranoside-6-phosphate, Cyclohexylammonium Salt,

Sign In for Pricing
View Details
CD3e (T-Cell Marker) (rC3e/2479), CF568 conjugate, 0.1mg/mL
BNC683790-500 1x 500 µL

CD3e (T-Cell Marker) (rC3e/2479), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
FAM38B / PIEZO2 Recombinant Rabbit monoclonal Antibody
HA723342 100 µL

FAM38B / PIEZO2 Recombinant Rabbit monoclonal Antibody

Sign In for Pricing
View Details
2-Benzamido-2-deoxy-D-glucopyranose (Alpha/Beta mixture)
TRC-B185000-5G 5 g

2-Benzamido-2-deoxy-D-glucopyranose (Alpha/Beta mixture)

Sign In for Pricing
View Details
OG488 BAPTA-1, hexapotassium salt [equivalent to Oregon Green® 488 BAPTA-1, hexapotassium salt] *Cell impermeant*
20506-AAT 500 µg

OG488 BAPTA-1, hexapotassium salt [equivalent to Oregon Green® 488 BAPTA-1, hexapotassium salt] *Cell impermeant*

Sign In for Pricing
View Details
Gel-BrightTM Imaging Hood
#E90005B 1 Each

Gel-BrightTM Imaging Hood

Sign In for Pricing
View Details