GNE-617

GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.

Product Specifications

CAS Number

[1362154-70-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-617.html

Purity

99.58

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(S(C2=CC(F)=CC(F)=C2)(=O)=O)C=C1)C3=CN4C(C=C3)=NC=C4

Molecular Formula

C21H15F2N3O3S

Molecular Weight

427.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19 (24) :6912-23.|[2]Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144 (1) :163-72.