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187-1, N-WASP inhibitor (TFA)

187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].

Product Specifications

UNSPSC

12352209

Target

Arp2/3 Complex

Type

Peptides

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/187-1-n-wasp-inhibitor-tfa.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC1=O)CCC(N)=O)N[C@H](C(N[C@@H](C(N2[C@@H](C(N[C@@H](C(N[C@H](C(N3[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N4[C@@H](C(N[C@@H](C(N[C@H](C(N5[C@@H]1CCC5)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)CCC4)=O)CC8=CC=CC=C8)=O)CCCCN)=O)CCC(N)=O)=O)CCC3)=O)CC9=CC=CC=C9)=O)CC%10=CC=CC=C%10)=O)CCC2)=O)CC%11=CC=CC=C%11)=O)CCCCN.O=C(O)C(F)(F)F

Molecular Formula

C98H123F3N18O18

Molecular Weight

1898.13

References & Citations

[1]Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98 (19) :10624-9.|[2]S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J Biol Chem. 2001 Aug 31;276 (35) :33175-80.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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