SMAPP1
SMAPP1 is an activator of protein phosphatase-1 (PP1) . SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus[1].
Product Specifications
CAS Number
327081-00-5
UNSPSC
12352005
Target
CDK; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/smapp1.html
Purity
99.43
Smiles
O=C(C1N(S(=O)(C2=CC=C(C)C=C2)=O)CC3=C(C=CC=C3)C1)NC4=CC=C(S(=O)(NC5=NC=CC=N5)=O)C=C4
Molecular Formula
C27H25N5O5S2
Molecular Weight
563.65
References & Citations
[1]Ammosova T, et al. Protein Phosphatase-1 Regulates Expression of Neuregulin-1. Biology (Basel) . 2016 Dec 2;5 (4) :49.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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