Anti-Mouse TIM-3 Antibody (RMT3-23)

Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse TIM-3 IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) . Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis[1][2][3].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

Tim3

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-tim-3-antibody-rmt3-23.html

Purity

95.00

Smiles

[Anti-MouseTIM-3Antibody(RMT3-23)]

Molecular Weight

(150 kDa)

References & Citations

[1]Nakayama M, et al. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood. 2009 Apr 16;113 (16) :3821-30.|[2]Nozaki Y, et al. Inhibition of the TIM-1 and -3 signaling pathway ameliorates disease in a murine model of rheumatoid arthritis. Clin Exp Immunol. 2024 Sep 16;218 (1) :55-64.|[3]Sabatos-Peyton CA, et al. Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy. Oncoimmunology. 2017 Nov 9;7 (2) :e1385690.