M77976
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].
Product Specifications
CAS Number
[394237-61-7]
Product Name Alternative
GMX1778,HPI-4
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/m77976.html
Purity
99.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
References & Citations
[1]Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67 (Pt 9) :763-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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