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M77976

M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].

Product Specifications

CAS Number

[394237-61-7]

Product Name Alternative

GMX1778,HPI-4

UNSPSC

12352005

Target

PDHK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/m77976.html

Purity

99.44

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C

Molecular Formula

C17H16N2O3

Molecular Weight

296.32

References & Citations

[1]Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67 (Pt 9) :763-73.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-114702/M77976-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-114702/M77976-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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