Carotegrast

Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis[1][2].

Product Specifications

CAS Number

[401904-75-4]

Product Name Alternative

HCA2969

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Carotegrast.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](NC(C1=C(Cl)C=CC=C1Cl)=O)CC2=CC=C(N3C(N(C)C4=C(C=C(N(C)C)C=C4)C3=O)=O)C=C2

Molecular Formula

C27H24Cl2N4O5

Molecular Weight

555.41

References & Citations

[1]Kazuyuki S, et al. Preparation of novel phenylalanine derivatives as α4 integrin inhibitors. WO 2003070709 A1|[2]Cheng Y, et al. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys. Clin Transl Sci. 2021 Sep;14 (5) :1924-1934.