LDV-FITC (TFA)
LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide. LDV-FITC TFA binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity[1][2].
Product Specifications
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldv-fitc-tfa.html
Smiles
OC(C(F)(F)F)=O.O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)=O)=O)CC(O)=O)=O)C(C)C)=O)=O)C)=O)C)=O)CCCCNC(NC4=CC5=C(C=C4)C6(OC5=O)C7=C(C=C(C=C7)O)OC8=C6C=CC(O)=C8)=S)O.[x]
Molecular Formula
C69H81N11O17S.xC2HF3O2
Molecular Weight
1368.51 (free base)
References & Citations
[1]Hyduk SJ, et al. Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood. 2007 Jan 1;109 (1) :176-84.|[2]Chigaev A, et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn (2+) or antibody activation. J Biol Chem. 2001 Dec 28;276 (52) :48670-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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