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(+) -JNJ-A07

(+) -JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+) -JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+) -JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1].

Product Specifications

CAS Number

2135640-93-4

UNSPSC

12352005

Target

Dengue Virus; Flavivirus; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/plus-jnj-a07.html

Concentration

10mM

Purity

98.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CCCOC1=CC(OC)=CC(NC(C2=CC=C(C=C2)Cl)C(N3C4=CC(OC(F)(F)F)=CC=C4CC3)=O)=C1)=O.[Rotation(+)]

Molecular Formula

C28H26ClF3N2O6

Molecular Weight

578.96

References & Citations

[1]Kaptein SJF, et al. A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction [published correction appears in Nature. 2021 Nov;599 (7883) :E2]. Nature. 2021;598 (7881) :504-509.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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