Methylisothiazolinone-d3 (hydrochloride)

Methylisothiazolinone-d3 hydrochloride is the deuterium labeled Methylisothiazolinone hydrochloride (HY-W010243) . Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels[1][2][3].

Product Specifications

CAS Number

[1329509-49-0]

UNSPSC

12352005

Hazard Statement

H410

Target

Apoptosis; Bacterial; Fungal; Isotope-Labeled Compounds; MMP

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Purity

99.42

Solubility

10 mM in DMSO

Smiles

O=C1N(SC=C1)C([2H])([2H])[2H].Cl

Molecular Formula

C4H3D3ClNOS

Molecular Weight

154.63

Precautions

H410

References & Citations

[1]Aynur O Aptula, et al. From Experiment to Theory: Molecular Orbital Parameters to Interpret the Skin Sensitization Potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol. 2005 Feb;18 (2) :324-9.|[2]Rubén Alvarez-Sánchez, et al. Covalent Binding of the 13C-labeled Skin Sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a Model Peptide and Glutathione. Bioorg Med Chem Lett. 2004 Jan 19;14 (2) :365-8.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.