1-Methylinosine

1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA. 1-Methylinosine is a metabolite and can be derived from inosine. 1-Methylinosine is remarkably higher in urine sample from breast cancer model[1][2].

Product Specifications

CAS Number

[2140-73-0]

Product Name Alternative

N1-Methylinosine

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-Methylinosine.html

Purity

99.89

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN(C)C3=O)=C3N=C2)O1

Molecular Formula

C11H14N4O5

Molecular Weight

282.25

Precautions

H315, H319, H335

References & Citations

[1]1-Methylinosine-Human Metabolome Database.|[2]Lei Hong, et al., Integration of Magnetic Dispersive Solid-Phase Micro-extraction with HPLC for Precise Detection of Tumor Markers 1-Methyladenosine and 1-Methylinosine in Urine Samples from Breast Cancer Patients. Chromatographia 87, 407–418 (2024) .