MEL24
MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1].
Product Specifications
CAS Number
[642072-48-8]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mel24.html
Purity
98.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1N(C)C(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1C)=O)=O
Molecular Formula
C17H18N4O3
Molecular Weight
326.35
References & Citations
[1]Ariel G Herman, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1 (4) :312-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
KIAA1680, CT (FAM190A, KIAA1680, Protein FAM190A) (Biotin) discontinued
YAP, CT (65kD Yes-associated Protein, YAP 65, YAP65, YAP-65, Yes Associated Protein 1 65kDa, Yes-associated Protein 1, YAp 1, YAP1, YAP2) (FITC) discontinued
![Mouse Monoclonal MMP-3 Antibody (MMP3/2655) [PE]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
