MEL24
Product Specifications
UNSPSC Description
MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mel24.html
Solubility
DMSO : 20 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1N(C)C(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1C)=O)=O
Molecular Weight
326.35
References & Citations
[1]Ariel G Herman, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1(4):312-25.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153215/MEL24-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153215/MEL24-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
642072-48-8
Available Sizes
Curated Selection
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