MEL24
MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1].
Product Specifications
CAS Number
[642072-48-8]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mel24.html
Purity
98.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1N(C)C(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1C)=O)=O
Molecular Formula
C17H18N4O3
Molecular Weight
326.35
References & Citations
[1]Ariel G Herman, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1 (4) :312-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal ZNF307 Antibody (OTI6G6) [DyLight 550]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
![Rabbit Polyclonal ARFGEF1 Antibody [DyLight 755]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
GnRH I (Progonadoliberin-1, Progonadoliberin I, Gonadoliberin-1, Gonadoliberin I, Gonadorelin, Gonadotropin-releasing Hormone I, GnRH-I, Luliberin I, Luteinizing Hormone-releasing Hormone I, LH-RH I, GnRH-Associated peptide 1, GnRH-Associated peptide I, GNRH1, GNRH, GRH, LHRH) discontinued