Levetiracetam

Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

Product Specifications

CAS Number

[102767-28-2]

Product Name Alternative

UCB L059

UNSPSC

12352005

Hazard Statement

H302, H319

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/levetiracetam.html

Purity

99.98

Solubility

DMSO : ≥ 85 mg/mL|H2O : ≥ 85 mg/mL

Smiles

NC([C@@H](N(CCC1)C1=O)CC)=O

Molecular Formula

C8H14N2O2

Molecular Weight

170.21

Precautions

H302, H319

References & Citations

[1]Bianca Maria Scicchitano, et al. Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Cancer Cell Int. 2018 Sep 10;18:136.|[2]Delia M Talos, et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013 Jan;73 (1) :24-30.