Tasimelteon-d5

Tasimelteon-d5 is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA) . Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [1][2].

Product Specifications

CAS Number

[1962124-51-1]

Product Name Alternative

BMS-214778-d5; VEC-162-d5

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Isotope-Labeled Compounds; Melatonin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Solubility

10 mM in DMSO

Smiles

[H][C@]1(C[C@H]1CNC(C([2H])(C([2H])([2H])[2H])[2H])=O)C2=C3CCOC3=CC=C2

Molecular Formula

C15H14D5NO2

Molecular Weight

250.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.|[3]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.