KMS88009
KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.
Product Specifications
CAS Number
[1089681-42-4]
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/kms88009.html
Smiles
CN(C)C1=CC=C(/C=C/C2=CC3=CC=C(C=C3O2)OC)C=C1
Molecular Formula
C19H19NO2
Molecular Weight
293.36
References & Citations
[1]Aminostyrylbenzofuran Directly Reduces Oligomeric Amyloid-b and Reverses Cognitive Deficits in Alzheimer Transgenic Mice
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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