Dynorphin A (Human)

<strong>Dynorphin A (Human)</strong> <strong>Catalog number:</strong> MDP0476 <strong>CAS Number: </strong>74927-14-3 <strong>Sequence: </strong>Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 2147.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Navarro VM. Metabolic regulation of kisspeptin - the link between energy balance and reproduction Nat Rev Endocrinol. 2020 Aug;16(8):407-420. 2: DeHaven RN, Mansson E, Daubert JD, Cassel JA. Pharmacological characterization of human kappa/mu opioid receptor chimeras that retain high affinity for dynorphin A Curr Top Med Chem. 2005;5(3):303-13. 3: Pomrenze MB, Cardozo Pinto DF, Neumann PA, Llorach P, Tucciarone JM, Morishita W, Eshel N, Heifets BD, Malenka RC. Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal Neuron. 2022 Dec 21;110(24):4125-4143.e6. 4: Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease Hum Reprod Update. 2014 Jul-Aug;20(4):485-500. 5: Hall SM, Lee YS, Hruby VJ. Dynorphin A analogs for the treatment of chronic neuropathic pain Future Med Chem. 2016;8(2):165-77. 6: Greenwald MK, Stitzer ML, Haberny KA. Human pharmacology of the opioid neuropeptide dynorphin A(1-13) J Pharmacol Exp Ther. 1997 Jun;281(3):1154-63. 7: Spampinato S, Ferri GL, Candeletti S, Romualdi P, Cavicchini E, Soimero L, Labò G, Ferri S. Regional distribution of immunoreactive dynorphin A in the human gastrointestinal tract Neuropeptides. 1988 Apr;11(3):101-5. 8: Best KM, Mojena MM, Barr GA, Schmidt HD, Cohen AS. Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder J Neurotrauma. 2022 Jan;39(1-2):1-19. 9: Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective Annu Rev Pharmacol Toxicol. 2016;56:511-33. <a href="https://pubmed.ncbi.nlm.nih.gov/9695716">10: Gambús PL, Schnider TW, Minto CF, Youngs EJ, Billard V, Brose WG, Hochhaus G, Shafer SL. Pharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers Clin Pharmacol Ther. 1998 Jul;64(1):27-38. </a> <br><strong>Products Related to Dynorphin A (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>