BIO-2007817
BIO-2007817 is a Parkin positive allosteric modulators (PAMs) . BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase) autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM) [1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bio-2007817.html
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CO[C@@H](C1=CN(N=C1)C)C(N2CC3=C(C=NN3C[C@H]2C(C)C)C4=CC=C(C=C4)C(N5CCCC6=C5C=CC=C6)=O)=O
Molecular Formula
C32H36N6O3
Molecular Weight
552.67
References & Citations
[1]Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25 (1) :103650.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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