D-Arabinose-d5

D-Arabinose-d5 is the deuterium labeled D-Arabinose (HY-N0059) . D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM) . D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) [1][2][3][4][5].

Product Specifications

UNSPSC

12352211

Target

AMPK; Bacterial; Isotope-Labeled Compounds; Parasite; PPAR

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C[C@@]([C@]([C@](C([2H])([2H])O)([2H])O)([2H])O)([2H])O

Molecular Formula

C5H5D5O5

Molecular Weight

155.16

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Guo Y, et al. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacol Res. 2024 Apr;202:107136.|[3]Sakoguchi H, et al. Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett. 2016 Feb 1;26 (3) :726-729.|[4]LeBlanc DJ, et al. Metabolism of D-arabinose: a new pathway in Escherichia coli. J Bacteriol. 1971 Apr;106 (1) :90-6.|[5]An SJ, et al. Inhibitory effect of d-arabinose on oral bacteria biofilm formation on titanium discs. Anaerobe. 2022 Jun;75:102533.