D-Arabinose-d5
D-Arabinose-d5 is the deuterium labeled D-Arabinose (HY-N0059) . D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM) . D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) [1][2][3][4][5].
Product Specifications
UNSPSC
12352211
Target
AMPK; Bacterial; Isotope-Labeled Compounds; Parasite; PPAR
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease; Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C[C@@]([C@]([C@](C([2H])([2H])O)([2H])O)([2H])O)([2H])O
Molecular Formula
C5H5D5O5
Molecular Weight
155.16
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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