Muscarinic Toxin 3

<strong>Muscarinic Toxin 3</strong> <strong>Catalog number:</strong> MDP0773 <strong>CAS Number: </strong>N/A <strong>Sequence: </strong>Leu-Thr-Cys-Val-Thr-Lys-Asn-Thr-Ile-Phe-Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Ala-Gly-Gln-Asn-Leu-Cys-Phe-Lys-Arg-Trp-His-Tyr-Val-Ile-Pro-Arg-Tyr-Thr-Glu-Ile-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ile-Pro-Glu-Asn-Tyr-Asp-Ser-Ile-His-Cys-Cys-Lys-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, and Cys58-Cys63) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 7379.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Wang JQ, Jolkkonen M, McGinty JF. The muscarinic toxin 3 augments neuropeptide mRNA in rat striatum in vivo Eur J Pharmacol. 1997 Sep 3;334(1):43-7. 2: Olianas MC, Adem A, Karlsson E, Onali P. Identification of rat brain muscarinic M4 receptors coupled to cyclic AMP using the selective antagonist muscarinic toxin 3 Eur J Pharmacol. 1998 Sep 18;357(2-3):235-42. 3: Olianas MC, Adem A, Karlsson E, Onali P. Rat striatal muscarinic receptors coupled to the inhibition of adenylyl cyclase activity: potent block by the selective m4 ligand muscarinic toxin 3 (MT3) Br J Pharmacol. 1996 May;118(2):283-8. 4: Olianas MC, Ingianni A, Maullu C, Adem A, Karlsson E, Onali P. Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors J Pharmacol Exp Ther. 1999 Jan;288(1):164-70. 5: Karlsson E, Jolkkonen M, Mulugeta E, Onali P, Adem A. Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors Biochimie. 2000 Sep-Oct;82(9-10):793-806. 6: Lee MC, Yang YC, Chen YC, Huang SC. Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase Scand J Gastroenterol. 2013 Feb;48(2):205-12. 7: Jerusalinsky D, Kornisiuk E, Alfaro P, Quillfeldt J, Alonso M, Verde ER, Cerveñansky C, Harvey A. Muscarinic toxin selective for m4 receptors impairs memory in the rat Neuroreport. 1998 May 11;9(7):1407-11. 8: Onali P, Olianas MC. Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens Eur J Pharmacol. 2002 Jul 19;448(2-3):105-11. 9: Nickla DL, Yusupova Y, Totonelly K. The Muscarinic Antagonist MT3 Distinguishes Between Form Deprivation- and Negative Lens-Induced Myopia in Chicks Curr Eye Res. 2015 Sep;40(9):962-7. <a href="https://pubmed.ncbi.nlm.nih.gov/7925952">10: Jolkkonen M, van Giersbergen PL, Hellman U, Wernstedt C, Karlsson E. A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors FEBS Lett. 1994 Sep 19;352(1):91-4. </a> <br><strong>Products Related to Muscarinic Toxin 3 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>