PROTAC SMARCA2/4-degrader-7
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s 90 after 24 h of treatment[1].
Product Specifications
CAS Number
2568277-89-2
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-7.html
Smiles
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC([C@@H]2CC[C@@H](C3=CN=C(N4C5CN(C6=C(N)N=NC(C7=C(C=CC=C7)O)=C6)CC4CC5)N=C3)CC2)=O)=O)NC8(C9=CC=C(C%10=C(N=CS%10)C)C=C9)CC8
Molecular Formula
C51H61N11O5S
Molecular Weight
940.17
References & Citations
[1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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