DIPPA (hydrochloride)

DIPPA hydrochloride is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA hydrochloride can be used for the research of anxiety and antidepressant[1][2][3][4].

Product Specifications

CAS Number

[155512-52-0]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H334, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dippa-hydrochloride.html

Purity

99.7

Solubility

DMSO : 24 mg/mL (ultrasonic; warming)

Smiles

O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl

Molecular Formula

C22H24Cl3N3OS

Molecular Weight

484.87

Precautions

H301, H315, H319, H334, H335

References & Citations

[1]Jones DC, et al. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80 (10) :1478-1486.|[2]Carr GV, et al. Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) . 2010;210 (2) :295-302.|[3]Costello GF, et al. 2- (3,4-Dichlorophenyl) -N-methyl-N-[2- (1-pyrrolidinyl) -1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. J Med Chem. 1991;34 (1) :181-189.|[4]Chang AC, et al. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. J Med Chem. 1994;37 (26) :4490-4498.