Nitrochin
Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].
Product Specifications
CAS Number
56-57-5
Product Name Alternative
4-NQO
UNSPSC
12352005
Hazard Statement
H350
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nitrochin.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]
Molecular Formula
C9H6N2O3
Molecular Weight
190.16
Precautions
H350
References & Citations
[1]Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37 (2) :506-518.|[2]Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230 (2-3) :151-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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