Nitrochin

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

Product Specifications

CAS Number

[56-57-5]

Product Name Alternative

4-NQO

UNSPSC

12352005

Hazard Statement

H350

Target

Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nitrochin.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]

Molecular Formula

C9H6N2O3

Molecular Weight

190.16

Precautions

H350

References & Citations

[1]Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37 (2) :506-518.|[2]Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230 (2-3) :151-63.