Picolinamide (Standard)
Picolinamide (Standard) is the analytical standard of Picolinamide. This product is intended for research and analytical applications. Picolinamide (2-Picolinamide) is an inhibitor of Poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].
Product Specifications
CAS Number
1452-77-3
Product Name Alternative
2-Picolinamide (Standard)
UNSPSC
12352005
Target
PARP; Reference Standards
Type
Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/picolinamide-standard.html
Smiles
O=C(C1=NC=CC=C1)N
Molecular Formula
C6H6N2O
Molecular Weight
122.12
References & Citations
[1]Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251 (1) :188-92. |[2]Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257 (11) :6084-8. |[3]Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95 (1) :474-81. |[4]amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly (adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45 (4) :1845-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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