Fenvalerate

Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

Product Specifications

CAS Number

[51630-58-1]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H410

Target

Bacterial; Phosphatase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fenvalerate.html

Concentration

10mM

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC(C#N)C1=CC=CC(OC2=CC=CC=C2)=C1)C(C(C)C)C3=CC=C(Cl)C=C3

Molecular Formula

C25H22ClNO3

Molecular Weight

419.90

Precautions

H301, H315, H319, H335, H410

References & Citations

[1]E Enan, et al. Specific Inhibition of Calcineurin by Type II Synthetic Pyrethroid Insecticides. Biochem Pharmacol. 1992 Apr 15;43 (8) :1777-84.|[2]A R Reilein, et al. Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A) . J Cell Biol. 1998 Aug 10;142 (3) :803-13.