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PF-05085727

PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) . PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11[1].

Product Specifications

CAS Number

1415637-72-7

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PF-05085727.html

Concentration

10mM

Purity

99.53

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CN1C2=NC=NC(N3CCC3)=C2C(C4=C(C5=CC=C(C(F)(F)F)C=C5)N(C)N=C4)=N1

Molecular Formula

C20H18F3N7

Molecular Weight

413.40

References & Citations

[1]Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60 (13) :5673-5698.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE2

Available Sizes

Frequently Asked Questions

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