PF-05085727
PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) . PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11[1].
Product Specifications
CAS Number
[1415637-72-7]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-05085727.html
Concentration
10mM
Purity
99.53
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CN1C2=NC=NC(N3CCC3)=C2C(C4=C(C5=CC=C(C(F)(F)F)C=C5)N(C)N=C4)=N1
Molecular Formula
C20H18F3N7
Molecular Weight
413.40
References & Citations
[1]Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60 (13) :5673-5698.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE2
Available Sizes
Curated Selection
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