Domperidone (monomaleate)

Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].

Product Specifications

CAS Number

[83898-65-1]

Product Name Alternative

R33812 (monomaleate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/domperidone-monomaleate.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)/C=C\C(O)=O.O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN4C5=CC=CC=C5NC4=O)CC3

Molecular Formula

C26H28ClN5O6

Molecular Weight

541.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102 (9) :2036-2045.|[2]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135 (5) :457-461.|[3]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124 (1) :52-60.