Afabicin

Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Product Specifications

CAS Number

[1518800-35-5]

Product Name Alternative

Debio 1450; AFN-1720

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Afabicin.html

Purity

96.28

Solubility

H2O : 3.85 mg/mL (ultrasonic; warming; adjust pH to 10 with NaOH; heat to 60°C)

Smiles

O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O

Molecular Formula

C23H24N3O7P

Molecular Weight

485.43

References & Citations

[1]Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015 May;59 (5) :2583-7.