PF-07258669
PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM) . PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa[1].
Product Specifications
CAS Number
[2755890-53-8]
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-07258669.html
Purity
98.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N=C(N1)C(CC[C@]21CCN(C([C@H](C)C3=C(C=NC(OC)=C3)F)=O)C2)=C4)=C4C5=NC=CC=N5
Molecular Formula
C25H27FN6O2
Molecular Weight
462.52
References & Citations
[1]Christopher Ryan BUTLER, et al. Spiro compounds as melanocortin 4 receptor antagonists and uses thereof. Patent. WO2021250541A1.|[2]Garnsey MR, et al., Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss. J Med Chem. 2023 Mar 9;66 (5) :3195-3211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MC4R
Available Sizes
Curated Selection
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