MuRF1-IN-1
MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
Product Specifications
CAS Number
445222-91-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/murf1-in-1.html
Purity
98.16
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=C(N)OC(CCCC2=O)=C2C13C(N(C)C4=C3C=CC=C4)=O
Molecular Formula
C18H15N3O3
Molecular Weight
321.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8 (6) :939-953.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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