MuRF1-IN-1

MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia[1].

Product Specifications

CAS Number

[445222-91-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/murf1-in-1.html

Purity

98.16

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N#CC1=C(N)OC(CCCC2=O)=C2C13C(N(C)C4=C3C=CC=C4)=O

Molecular Formula

C18H15N3O3

Molecular Weight

321.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8 (6) :939-953.