PBD-monoamide
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC) . PBD-monoamide has DNA-binding activity and reduces cell viability[1].
Product Specifications
CAS Number
2093165-00-3
UNSPSC
12352203
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbd-monoamide.html
Purity
96.41
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OCCCCCOC2=C(OC)C=C3C(N=C[C@@]([H])(N(C3=O)C4)CC4=C)=C2)C=C1NC5=O)N([C@]5(C6)[H])CC6=C
Molecular Formula
C33H36N4O7
Molecular Weight
600.66
References & Citations
[1]Lewis GD, et al. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results. Nat Commun. 2024 Jan 11;15 (1) :466.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
