PBD-monoamide
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC) . PBD-monoamide has DNA-binding activity and reduces cell viability[1].
Product Specifications
CAS Number
2093165-00-3
UNSPSC
12352203
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbd-monoamide.html
Purity
96.41
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OCCCCCOC2=C(OC)C=C3C(N=C[C@@]([H])(N(C3=O)C4)CC4=C)=C2)C=C1NC5=O)N([C@]5(C6)[H])CC6=C
Molecular Formula
C33H36N4O7
Molecular Weight
600.66
References & Citations
[1]Lewis GD, et al. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results. Nat Commun. 2024 Jan 11;15 (1) :466.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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