2-Iminobiotin

2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

Product Specifications

CAS Number

[13395-35-2]

Product Name Alternative

Guanidinobiotin

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-iminobiotin.html

Purity

99.95

Solubility

DMSO : 9.09 mg/mL (ultrasonic; adjust pH to 6 with 1 M HCl)

Smiles

[H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N

Molecular Formula

C10H17N3O2S

Molecular Weight

243.33

Precautions

H302, H312, H332

References & Citations

[1]Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204 (2) :962-8.|[2]Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.