SMS121

SMS121 is a CD36 inhibitor with a KD values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Scavenger Receptor Class B type I (SR-BI)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sms121.html

Concentration

10mM

Purity

99.06

Solubility

DMSO : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)COC1=CC=C(/C=C/C(C2=CC=C(N(C)C)C=C2)=O)C=C1OC

Molecular Formula

C20H21NO5

Molecular Weight

355.38

References & Citations

[1]Åbacka H, et al. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia[J]. Scientific Reports, 2024, 14 (1) : 9104.