Cis-VZ185
Cis-VZ185 is a VHL-based PROTACs degrader with the activity of degrading BRD9 and BRD7. cis-VZ185 can be optimized from suboptimal compounds by optimizing the connection mode and linker, and has efficient, rapid and selective degradation of BRD9 and its homologous protein BRD7.
Product Specifications
CAS Number
2306193-98-4
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cis-vz185.html
Smiles
CN1C=C(C2=CC=NC=C2C1=O)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@@H](O)C6)=O)C=CC(C8=C(N=CS8)C)=C5)CC4)C(OC)=C3
Molecular Formula
C53H67FN8O8S
Molecular Weight
995.21
References & Citations
[1]Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) …
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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