KWWCRW

KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro[1].

Product Specifications

CAS Number

292148-25-5

UNSPSC

12352209

Target

DNA/RNA Synthesis

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kwwcrw.html

Smiles

NCCCC[C@H](N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O

Molecular Formula

C48H61N13O7S

Molecular Weight

964.15

References & Citations

[1]Qingbing Wang, et al. "Recent Advancements on Self‐Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads." Advanced healthcare materials 12.20 (2023) : 2300138.